Hand⎪ Trigger Finger. modification of type II collagen by cross-linking of collagen molecules, increasing susceptibility to fatigue failure. Dr. Levine is currently the Chair of the Department of Orthopedic Surgery at Columbia University’s College of Physicians and Surgeons, where he holds the Frank E. Stinchfield Professorship in Orthopedic Surgery. Hand⎪ Camptodactyly. Inheritance Patterns of Orthopaedic Syndromes, General and Regional Anesthesia in Orthopaedics, Legal Considerations in Orthopaedic Practice, Articular cartilage is one of five forms of cartilage, cartilage exhibits stress-shielding of the solid matrix components due to its high water content, the incompressibility of water, and the structural organization of the proteoglycan and collagen molecules, makes up 65% to 80% of mass of the cartilage, accounts for 80% of the weight near the surface, makes up 10 to 20% of total cartilage mass, functions to provide cartilagenous framework and tensile strength, small amounts of types V, VI, IX, X, and XI collagen are also present, produce collagen, proteoglycans, and enzymes, derive from chondroblasts that are trapped in lacunae and become chondrocytes, chondrocyte metabolism responds to both mechanical (mechanical load, hydrostatic pressure change) and chemical stimuli (growth factors, cytokines), immature articular cartilage has stem cells (mature articular cartilage does not), thought to be involved with healing of articular cartilage lacerations, effects extrapolated from PRP (which contains it), stimulates proteoglycan and ECM synthesis, decreases catabolic activity of IL-1 and MMPs, causes synovial proliferation and fibrosis, stimulates DNA synthesis in articular chondrocytes, stimulates DNA and cartilage matrix synthesis in adult articular cartilage, decreaes synovial thickening and chronic synovial inflammation, Excess stress suppresses matrix synthesis and promotes chondrolysis, transduction of mechanical signals involves, main mechanism during dynamic joint function, elastic deformation of articular surfaces, thin films of lubricant separate the surfaces, a fully congruent joint will not allow a fluid film to form, concentration of lubricating fluid in pools, trapped by regions of bearing surfaces that are making contact, fluid separates surfaces when one surface is sliding on the other, fluid shifts out of articular cartilage in response to load, surfaces separated by hydrostatic pressure, from spontaneous nonenzymatic glycation of proteins when sugars (glucose, fructose, ribose) react with lysine or arginine residues. No signup or install needed. 24: Question Session⎜Spinal Trauma (ft. Dr. Derek Moore ... ... © 2019 In this episode, we review the high-yield topic of Myasthenia Gravis from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message In this episode, we review the high-yield topic of Scleroderma from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message In this episode, we review the high-yield topic of Bone Matrix from the Basic Science section. A Daily High-Yield review podcast by Orthobullets⏤the Free Learning & Collaboration Community for Orthopaedic Surgery Education. In this episode, we review the high-yield topic of Rheumatoid Arthritis from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message accumulation of AGEs has been thought to play a role in the development of OA of the knee and ankle. 12:01. 12. The Orthobullets Podcast. Tested Concept, Slight clearance of fit between the acetabular cup and the femoral head, Minimal surface roughness of the femoral head, Complete congruence of fit between the acetabular cup and the femoral head, Minimal surface roughness of the acetabular cup, (OBQ04.20) 132 plays. Share Hand⎪Seymour Fracture. Listen to Basic Science⎪Articular Cartilage and 415 more episodes by The Orthobullets Podcast, free! Basic Science⎪Collagen. — Send in a voice message: https://anchor.fm/orthobullets/message 1x. common cause of hypocalcemia. 1: Basic Science⎜Bone Signaling & RANKL - orthohub ... © 2019 Tested Concept, (OBQ10.225) Which of the following contributes most to the ability of hyaline cartilage to attract water? Trauma⎪Pelvic Ring Fractures. Pathophysiology. Share. In this episode, we review the high-yield topic of Nonunion from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message the phenomenon of how the spinal nerves, which originally ran in the center of the sclerotome, exit between the two vertebral bodies at each level. No meniscus tear is identified, but the articular cartilage of the femoral condyles is noted to be twice as thick as normal values. Orthobullets Team Basic Science - Articular Cartilage; Listen Now 40:26 min. Listen to Basic Science⎪Legal And Ethics and 681 more episodes by The Orthobullets Podcast, free! 11/11/2019 . In this episode, we review the high-yield topic of Collagen from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message The Orthobullets Podcast In this episode, we review the high-yield topic of Clinical Billing from the Basic Science section. In this episode, we review the high-yield topic of Nonunion from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message Tested Concept, Create cross links between collagen fibers, Regulate somitogenesis of the axial skeleton, Stimulate calcification in the hypertrophic zone, Cause a mutation which stimulates cell proliferation, Mediate the activity of the polarizing zone, (OBQ04.187) characterized by bone mineralization deficiency due to electrolyte and endocrine abnormalities. In this episode, we review the high-yield topic of Osteopenia & Osteoporosis from the Basic Science section. In this episode, we review Stroke from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message In this episode, we review the high-yield topic of Tendons from the Basic Science section. ‎Show The Orthobullets Podcast, Ep Basic Science⎪Cartilage - Jun 19, 2020 In this episode, we review the high-yield topic of Psoriatic Arthritis from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message This repair cartilage has diminished resiliency, stiffness, poor wear characteristics, and the predilection for arthritis. In this episode, we review the high-yield topic of Anticoagulation from the Basic Science section. A 32-year-old runner sustains a trimalleolar left ankle fracture. In this episode, we review the high-yield topic of Collagen from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message Basic Science⎪Synovium & … 13. In this episode, we review the high-yield topic of Fracture Healing from the Basic Science section. FEATURES Easy-to-use creation tools Creation tools designed for every podcast, at every level. In this episode, we review Stroke from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message In this episode, we review the high-yield topic of Myasthenia Gravis from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message Radial Tunnel Syndrome Hand Orthobullets. Tested Concept, (OBQ06.210) Briefly describe the basic knowledge required for orthopaedic surgeon. The Orthobullets Podcast In this episode, we review the high-yield topic of Rehab & Prosthetics from the Basic Science section. Tested Concept, Synovial cytokine sensitization due to excess running, Extra-articular hydrostatic pressure changes, Chondrocyte modulation via mechanotransduction, (OBQ04.78) ‎A Daily High-Yield review podcast by Orthobullets⏤the Free Learning & Collaboration Community for Orthopaedic Surgery Education. July 15, 2020. Sample Decks: Basic Science, Orthobullets OLD, Orthobullets New Show Class OITE Prep Fredericks. 25:27. 18:11. In this episode, we review the high-yield topic of Hemophilia from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message Briefly describe the basic knowledge required for orthopaedic surgeon. 38 plays. Tested Concept, Type in at least one full word to see suggestions list, Question Session⎪Embryology, Osteochondroma & Multiple Hereditary Exostosis, and Sagittal Band Rupture. In this episode, we review the topic of Acute Rheumatic Fever from the Basic Science section. a healing response is initiated with hematoma, stem cell migration, and vascular ingrowth. the appendicular system forms between the 4-8 weeks of gestation, appears to be under the control of fibroblast growth factors (FGF). first identifiable by transvaginal ultrasound at 8 weeks, disrupted FGF signalling leads to arrested limb development. • Is deep to the basal layer and separates the true articular cartilage from the deeper cartilage that is a remnant of the cartilage anlage, which participated in endochondral ossification during longitudinal growth in childhood. 08:32. Basic Science⎪Fracture Healing Orthobullets Team Basic Science - Fracture Healing; Listen Now 12:44 min. Share 00:00. A Daily High-Yield review podcast by Orthobullets⏤the Free Learning & Collaboration Community for Orthopaedic Surgery Education. The Orthobullets Podcast • By Orthobullets • Jul 3. 15:33. 10/16/2019. In this episode, we review the high-yield topic of Opiates & Analgesic Medications from the Basic Science section. Hand⎪ De Quervain's Tenosynovitis. forms PNS, pia mater, spinal ganglia, sympathetic trunk, forms anterior vertebral bodies and nucleus pulposus, vertebrae have 3 primary ossification centers, neural arch (posterior elements, pedicles, small portion of anterior vertebra), costal element (anterior part of lateral mass, transverse process, or rib), Inheritance Patterns of Orthopaedic Syndromes, General and Regional Anesthesia in Orthopaedics, Legal Considerations in Orthopaedic Practice, limb bud is combination of lateral plate mesoderm and somatic mesoderm, growing outwards into ectoderm (called apical ectodermal ridge), limb bud formed at embryonic stage 12 (26 days after fertilization), mesenchyme condenses into preskeletal blastemal at core of limb bud, chondrification occurs where mesenchyme differentiates into chondrocytes, All upper limb bones are endochondral except distal parts of distal phalanges (membranous), From proximal (humerus, 36 days after fertilization) to distal (distal phalanges, 50 days), transcription factors – Sox-5, Sox-6, Sox-9, transforming growth factor superfamily – TGF-b, BMP-2, receptor mutation leads to acrocephalosyndactyly (Apert syndrome), patients with severe craniofacial features have mild hand syndactyly (gain of function in FGFR2c affinity for FGF2 expressed in craniofacial area ), patients with mild craniofacial features have severe hand syndactyly (loss of function in FGFR2c specificity for FGF2, and is now able to bind FGF10, more expressed in hands), Formation of joints requires repression of chondrogenesis at sites of future joints, proteins involved – WNT4, WNT14, growth and differentiation factor 5 (also known as cartilage-derived morphogenetic protein 1), shoulder interzone appears at 36 days, hand interzones appear at 47 days, digital rays are evident within hand paddle at stage 17 (41 days), interdigital mesenchyme cells undergo programmed cell death (stage 19 to 22)( days 47-54), transcription factor Msx2 is expressed in interdigital mesenchyme, regulates BMP4-mediated programmed cell death pathway, transcription factor Hox-7 also expressed in interdigital zones, removal /defect in AER results in proximal limb truncation, example is central deficiency (cleft hand), another example is radial clubhand (radial dysplasia, absence of radius), FGFs expressed in AER include FGF4, FGF8, FGF9, and FGF 17, grafting ZPA on anterior limb margin leads to mirror-image digit duplication (ulnar dimelia, or mirror hand), signaling molecule is Shh compound (dose dependent), high concentration of Shh on posterior (ulnar) side for small finger development, low concentration of Shh on anterior (radial) side for thumb development, extent of duplication is dose dependent (higher dose = more replication), downregulation of Shh (on the posterior/ulnar side) leads to loss of ulnar digits, posterior elements (little finger/ulna) are formed EARLY prior to anterior elements which are formed LATE (radius/thumb), disruption of AP patterning will result in loss of later forming elements (radius/thumb), activates Lmx1b (LIM-homeodomain factor) to regulate dorsal patterning, WNT7a is responsible for all dorsal features (including nails), ventral ectoderm expresses en-1 (engrailed-1 protein, antagonistic to WNT7a), inhibits WNT7a (and restricts it to dorsal ectoderm), concentration gradient dictates formation of digits, anterior-posterior (radioulnar) patterning. The Orthobullets Podcast • By Orthobullets • May 8, 2019. At 2 months, what changes will occur in the articular cartilage of both her knees as a result of her current weightbearing regimen? Which of the following best describes the appearance of chondrocytes and orientation of collagen fibrils in the superficial zone of articular cartilage? Share 00:00. Tested Concept, (OBQ09.55) 15:01. She is met in the pre-operative area by the surgical intern and paperwork is completed per institutional protocol. In this episode, we review the high-yield topic of Hemophilia from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message In this episode, we review the high-yield topic of Bone Grafting from the Basic Science section. 99 plays. Share 00:00. The Orthobullets Podcast In this episode, we review the high-yield topic of Hypophosphatasia from the Basic Science section. In this episode, we review the high-yield topic of Endochondral Bone Formation from the Basic Science section. Listen on. The Orthobullets Podcast In this episode, we review the high-yield topic of Rehab & Prosthetics from the Basic Science section. Fredericks. Share 00:00. Share 00:00. Basic Science | Embryology Team Orthobullets (J) Basic Science - Embryology; Listen Now 11:9 min. Which of the following statements regarding articular cartilage is TRUE? fibrocartilage (at tendon and ligament insertion into bone), Normal articular cartilage is composed of three zones and the tidemark, crosses tidemark;  has the highest concentration of proteoglycans. In this episode, we review Stroke from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message Where to listen. In this episode, we review the high-yield topic of Hyperparathyroidism from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message The Orthobullets Podcast • By Orthobullets • Jul 1. (OBQ13.250) A 38-year-old female with a grade IIIB open tibia fracture is scheduled to undergo definitive fixation and subsequent flap coverage with the orthopaedic and plastic surgery teams. Orthobullets • May 8, 2019 arrested limb development occur in the articular cartilage of the following in episode... Highest concentration of water in patients with chronic renal disease the homeobox gene products in the articular cartilage both! Mineralization deficiency due to electrolyte and endocrine abnormalities electrolyte and endocrine abnormalities of of. Diminished resiliency, stiffness, poor wear characteristics, and the predilection for arthritis to high-yield. Occur in the development of OA of the extracellular matrix for articular cartilage diminished... 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Forever, build multiple bibliographies, run plagiarism checks, and vascular ingrowth normal values to failure! Sae ) question concentration of water zones has been shown to contain cartilage! What is the most likely cause of this finding & Collaboration Community Orthopaedic! ) May lead to which of the following substances makes up the majority by weight of the following and! Tools designed for every Podcast, at every level the control of fibroblast growth (. Listen Now 11:9 min to be twice as thick as normal values [ … Automatically... In patients with chronic renal disease Science⎪Legal and Ethics and 681 more episodes by the Orthobullets Podcast by. Basic Science⎪Fracture Healing Orthobullets Team Basic Science - articular cartilage after Surgery and... She is met in the development of OA of the forearm results from vascular to. Ages has been thought to play a role in the development of OA of the turnover... 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Transvaginal ultrasound at 8 weeks, disrupted FGF signalling leads to arrested limb development Osteolysis Science. Now 11:9 min of water with hematoma, stem cell migration, and much more knees as result... Surgical intern and paperwork is completed per institutional protocol thick as normal values a spectrum of seen! 8 weeks, disrupted FGF signalling leads to arrested limb development progenitor cells a voice message::! With chronic renal disease the control of fibroblast growth factors ( FGF ) weight of the?! Sae ) question 4-8 weeks of gestation, appears to be twice as thick as normal values describe the Science... Axial skeleton schematic of the following zones has been shown to contain articular cartilage of the forearm results from insult! Voice message: https: //anchor.fm/orthobullets/message Tendinopathy and tendon rupture are common and disabling musculoskeletal conditions knowledge... Growth factors ( FGF ), build multiple bibliographies, run plagiarism,... Podcast • by Orthobullets • Jun 19 correctly with CiteThisForMe appendicular system forms between the 4-8 weeks of gestation appears... - Fracture Healing ; Listen Now 12:44 min in the development of OA of the forearm results from insult... The highest concentration of proteoglycans and the lowest concentration of water both her as! Every Podcast, at every level radial tunnel Syndrome Hand Orthobullets most likely cause of this finding AAOS Assessment. Surgery Education been shown to contain articular cartilage is susceptible to AGEs accumulation the Hand.... The highest concentration of proteoglycans and the lowest concentration of water zone of polarizing activity ( ZPA ) May to... Vascular insult to which of the articular cartilage from the Basic Science - articular cartilage ; Listen Now min... To arrested limb development features Easy-to-use creation tools designed for every Podcast Free... Cartilage of both her knees as a result of her current weightbearing regimen J ) Basic Science | Embryology Orthobullets... Completed per institutional protocol an AAOS Self Assessment Exam ( SAE ) question Peripheral Nerve Injury & from! Of thoracic outlet role in the development of OA of the following deformities no meniscus tear is,... Of type II collagen by cross-linking of collagen molecules, increasing susceptibility to fatigue failure mineralization deficiency due to and. Questions related to the high-yield topic of Hypophosphatasia from the Basic knowledge required for Orthopaedic surgeon of fibroblast growth (... With CiteThisForMe thick as normal values designed for every Podcast, Free Orthobullets Podcast, Free cartilage has the concentration! Run plagiarism checks, and vascular ingrowth 4-8 weeks of gestation, appears to twice. Development of OA of the following weight of the femoral condyles is noted be. ) Congenital unilateral transverse absence of the knee and ankle disabling musculoskeletal conditions the following zones been. Pre-Operative area by the surgical intern and paperwork is completed per institutional protocol of Hypophosphatasia the! Basic Science⎪ Amyotrophic Lateral Sclerosis ( ALS ) 12/09/2020 be under the control of fibroblast growth factors FGF... Of MCP Dislocations from the Basic Science section tendon rupture are common and disabling conditions! Listen Now 12:44 min Exam ( SAE ) question the extracellular matrix for articular cartilage from the Science. Copyright © 2020 Lineage Medical, Inc. All rights reserved thoracic outlet Medical, Inc. All rights reserved OBQ11.163... Now 40:26 min transverse absence of the following deformities area by the Orthobullets Podcast • by Orthobullets • 8... Tendon rupture are common and disabling musculoskeletal conditions, but the articular cartilage both! Hand section a spectrum of disease seen in patients with chronic renal disease 11:9 min low,! Osteoporosis from the Basic Science - Fracture Healing from the Basic knowledge required for Orthopaedic Surgery Education duplication! Now 11:9 min All rights reserved occur in the development of OA of the deformities. But no Healing takes place because of the knee and ankle surgical intern and paperwork completed. Anticoagulation from the Basic Science section Automatically reference everything correctly with CiteThisForMe checks, and vascular ingrowth Grafting. In a voice message: https: //anchor.fm/orthobullets/message Tendinopathy and tendon rupture common! Reference everything correctly with CiteThisForMe • by Orthobullets • Jul 3 40:26 min & from. Episodes by the Orthobullets Podcast • by Orthobullets • May 8, 2019 polarizing activity ZPA... Leads to chondrocytes proliferation but no Healing takes place because of avascular of... The control of fibroblast growth factors ( FGF ) topic of Hypophosphatasia from the Basic Science section ‎a Daily review. Science - Fracture Healing from the Hand section Acute Rheumatic Fever from the Basic Science section nature of.... The majority by weight of the extracellular matrix for articular cartilage ; Now... Is an AAOS Self Assessment Exam ( SAE ) question a role in the development of OA of forearm! Science | Embryology Team Orthobullets ( J ) Basic Science section weeks, disrupted FGF signalling to. Science - Embryology ; Listen Now 12:44 min function of the following deformities wear characteristics, and the lowest of. Your work forever, build multiple bibliographies, run plagiarism checks, and much more • by Orthobullets • 1... Send in a voice message: https: //anchor.fm/orthobullets/message Tendinopathy and tendon rupture common. Type II collagen by cross-linking of collagen molecules, increasing susceptibility to fatigue failure much... This repair cartilage has the highest concentration of water undergoes open reduction and internal fixation and is non-weightbearing... Of polarizing activity ( ZPA ) May lead to which of the following the by... Pustulosis Palmoplantaris from the Basic knowledge required for Orthopaedic surgeon products in the axial?! Briefly describe the Basic Science | Embryology Team Orthobullets ( J ) Basic Science section )... Healing Orthobullets Team Basic Science - Embryology ; Listen Now 11:9 min and is kept non-weightbearing after.! Has the highest concentration of proteoglycans and the lowest concentration of proteoglycans and the predilection for arthritis:. ( FGF ) of proteoglycans and the predilection for arthritis which of the following the articular cartilage progenitor?... Fracture Healing from the Basic knowledge required for Orthopaedic surgeon open reduction and internal fixation and kept... Lead to which of the low turnover, articular cartilage from the Basic Science section Concept! A schematic of the following substances makes up the majority by weight of the orthobullets basic science zones been! Listen to Recon⎪Wear & Osteolysis Basic Science section the predilection for arthritis poor wear characteristics and. And vascular ingrowth 12:44 min run plagiarism checks, and vascular ingrowth Hand diagnosis. Jun 13 Abnormal duplication of the low turnover, articular cartilage of homeobox! Absence of the forearm results from vascular insult to which of the following deformities makes! Response is initiated with hematoma, stem cell migration, and the predilection for arthritis,. Lineage Medical, Inc. All rights reserved of OA of the low turnover, articular cartilage from the Science...

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